PDE5 Inhibitors: Vascular Optimization for Longevity
Medications developed for erectile dysfunction are being recognized for broader longevity benefits. Observational studies associate PDE5 inhibitors (tadalafil, sildenafil) with reduced cardiovascular disease, lower dementia risk, and decreased overall mortality.
The mechanism is vascular optimization: improved endothelial function, enhanced nitric oxide signaling, and better microcirculation — improving systemic blood flow, oxygen delivery, and cellular function.
At Extension Health we often include low-dose tadalafil (5 mg daily) in longevity protocols to support heart, brain, metabolic health, and sexual performance. This approach focuses on treating root causes and restoring resilience to extend healthy years.
